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#1 Life & Medicine
Shinya Yamanaka
born 1962
Created iPSCs — any cell can be reset and reborn — and is now turning regenerative medicine into reality
Achievements
- Nobel Prize in Physiology or Medicine (2012) — induced pluripotent stem cells
- Director of CiRA, Kyoto University, leading clinical applications
- World-first iPSC transplants: cornea, heart muscle, Parkinson's
Books
- Kyokuteki no saki ni (Beyond the Twists)
Links
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#2 Physics & Chemistry
Takaaki Kajita
born 1959
Confirmed neutrino oscillation with Super-Kamiokande, redrawing the map of particle physics
Achievements
- Nobel Prize in Physics (2015) — discovery of neutrino oscillations
- Led the Super-Kamiokande experiment
- Drove the creation of the gravitational-wave telescope KAGRA
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#3 Life & Medicine
Susumu Tonegawa
born 1939
Solved how antibodies achieve their diversity, then moved to the front line of memory research
Achievements
- Nobel Prize in Physiology or Medicine (1987) — genetic principle of antibody diversity
- Directed the Picower Institute at MIT, mapping memory circuits
- Pioneered direct experimental study of engrams
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#4 Physics & Chemistry
Akira Yoshino
born 1948
Invented the lithium-ion battery — the power source of modern civilization, from phones to EVs
Achievements
- Nobel Prize in Chemistry (2019) — invention of the lithium-ion battery
- First mass production in 1991; now powers nearly every device
- Continues to shape the next energy society
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#5 Life & Medicine
Tasuku Honjo
born 1942
Discovered PD-1, the immune system's brake — and a whole new way to treat cancer by releasing it
Achievements
- Nobel Prize in Physiology or Medicine (2018) — cancer immunotherapy via PD-1
- Commercialized as nivolumab (Opdivo), changing cancer care
- A symbol of how basic research saves lives
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#6 Physics & Chemistry
Yasunori Nomura
born 1974
A world leader in multiverse and inflation theory, directing the Berkeley Center for Theoretical Physics
Achievements
- Professor at UC Berkeley; director of the Berkeley Center for Theoretical Physics
- Front-line theory of inflation, the multiverse and quantum gravity
- Widely known in Japan as a “genius of quantum mechanics”
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#7 Physics & Chemistry
Syukuro Manabe
born 1931
First showed with numerical models that CO2 warms the Earth — the foundation of climate science
Achievements
- Nobel Prize in Physics (2021) — physical modelling of Earth's climate
- Pioneered atmosphere–ocean simulation in the 1960s
- Built the direct basis of today's IPCC climate projections
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#8 Physics & Chemistry
Shuji Nakamura
born 1954
Achieved the “impossible” blue LED and changed the world's lighting forever
Achievements
- Nobel Prize in Physics (2014) — the efficient blue LED
- Built GaN semiconductor mass-production almost single-handedly
- Professor at UC Santa Barbara, researching next-generation semiconductors
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#9 AI & Computing
Kunihiko Fukushima
born 1936
Invented the Neocognitron — the direct ancestor of convolutional neural networks, the eyes of modern AI
Achievements
- Neocognitron (1980) — precursor of the CNN
- Realized hierarchical visual processing decades before deep learning
- A quiet giant whom every history of AI must mention
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#10 AI & Computing
Shun-ichi Amari
born 1936
Created information geometry, laying the mathematical foundation of neural networks decades early
Achievements
- Founder of information geometry — a shared language of machine learning
- Established learning rules and recurrent-network theory in the 1960s–70s
- B.J. Boltzmann Award (2022) and other honors
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#11 Physics & Chemistry
Ryoji Noyori
born 1938
Established asymmetric catalysis — making molecules in a single handedness — and changed medicinal chemistry
Achievements
- Nobel Prize in Chemistry (2001) — asymmetric hydrogenation catalysis
- BINAP catalysts are used directly in industrial drug synthesis
- A leading advocate of green chemistry
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#12 Life & Medicine
Shimon Sakaguchi
born 1951
Reframed immunity as something that also must stop — via regulatory T cells, rebuilding immunology
Achievements
- Discovery of regulatory T cells (1995) and their molecular basis (2003)
- Opened new therapeutic targets for autoimmunity, cancer and transplant
- A recurring name in Nobel predictions worldwide
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#13 Life & Medicine
Kazutoshi Mori
born 1957
Solved how cells cope with misfolded proteins — the unfolded protein response
Achievements
- Elucidated the molecular machinery of the unfolded protein response
- Lasker Award (2014) among Nobel-level honors
- Foundation for understanding diabetes and neurodegeneration
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#14 Physics & Chemistry
Hideo Hosono
born 1953
Started two materials revolutions by himself: IGZO oxide semiconductors and iron-based superconductors
Achievements
- Discovery of iron-based high-temperature superconductors (2006-08)
- IGZO oxide semiconductor — transformed displays in mass production
- Among the most influential materials scientists alive
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#15 Physics & Chemistry
Susumu Kitagawa
born 1951
Built the world of porous materials (MOF/PCP) that soak up gases — the basis of carbon capture and storage
Achievements
- World pioneer of porous coordination polymers (MOF/PCP)
- Materials foundation for climate technology: gas separation and storage
- Recipient of multiple top international prizes
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#16 Physics & Chemistry
Koichi Tanaka
born 1959
Won the Nobel as a corporate engineer, then kept working at the bench — a rarity among laureates
Achievements
- Nobel Prize in Chemistry (2002) — soft laser desorption ionization
- Made protein mass spectrometry possible, enabling early diagnosis
- Continues industrial research at Shimadzu
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#17 Life & Medicine
Yoshihiro Kawaoka
born 1955
The world's top influenza researcher — studying “the next pandemic” before it arrives
Achievements
- Elucidated infection and mutation mechanisms of influenza viruses
- World authority on high-containment (BSL-4) virus research
- Lasker Award and more; feeds vaccine development directly
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#18 Life & Medicine
Yusuke Nakamura
born 1952
Mapped Japanese genome variation at scale and built cancer genome medicine as a clinical reality
Achievements
- Pioneer of Japanese genome analysis and SNP markers
- Led clinical application of cancer genome profiling
- University of Chicago professor; NCRI leadership in Japan
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#19 Mathematics
Shinichi Mochizuki
born 1961
Attacked the ABC conjecture with his own inter-universal Teichmüller theory — mathematics' most debated figure
Achievements
- Challenge to the ABC conjecture (2012) — one of number theory's biggest problems
- Constructed the inter-universal Teichmüller theory (IUT)
- Entered Princeton University at 16
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#20 Mathematics
Shigefumi Mori
born 1951
Completed the minimal model program in dimension 3 — Japan's first Fields Medalist
Achievements
- Fields Medal (1990) — contributions to algebraic geometry
- Established the 3-dimensional minimal model program
- Professor at Kyoto University, training the next generation
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#21 Mathematics
Kenji Fukaya
born 1956
Created the Fukaya category — a new language linking symplectic geometry and physics' mirror symmetry
Achievements
- The Fukaya category — a central object of symplectic geometry
- Theory of Gromov–Witten invariants
- Breakthrough Prize in Mathematics (2024)
Books
- Chōron-ron (On Abstraction)
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#22 Mathematics
Masaki Kashiwara
born 1947
Built D-module theory and crystal bases — infrastructure connecting representation theory, geometry and physics
Achievements
- Establishment of D-module theory
- Discovery of crystal (global) bases — a dictionary for representation theory
- Chern Medal (2018) and many international honors
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#23 Mathematics
Toshiyuki Kobayashi
born 1962
Opened “micro-local” analysis of representations, bridging discrete and continuous structures
Achievements
- Pioneer of micro-local analysis in representation theory
- Fundamental results on affine symmetric spaces
- Active in public outreach for mathematics
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#24 Mathematics
Takeshi Saito
Quietly builds the deep theorems of arithmetic geometry that support the Langlands program
Achievements
- Foundational results on cohomology of schemes and function fields
- Important theorems on weights of L-functions
- Professor at Tokyo University, leading Japan's arithmetic geometry hub
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#25 Culture & Arts
Sota Fujii
born 2002
Turned professional at 14 and became the youngest ever to hold every shogi title — a new era of the game
Achievements
- 29 consecutive wins at debut (all-time record); youngest title holder in history
- Complete domination of all eight major shogi titles
- Defined the standard style of the AI era in shogi
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#26 Culture & Arts
Shohei Ohtani
born 1994
Achieved two-way play — hitting and pitching — a feat unseen for a century, at baseball's highest level
Achievements
- Established modern two-way play in Major League Baseball
- First-ever 50 home runs + 50 stolen bases season (2024)
- Sports' largest contract (2023) reshaped the market
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#27 Culture & Arts
Shigeru Miyamoto
born 1952
Created Mario and Zelda, turning video games into a shared global language
Achievements
- Created Super Mario, The Legend of Zelda, Donkey Kong
- Built the very grammar of game design
- Honored far beyond games (Praemium Imperiale and more)
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#28 Culture & Arts
Satoshi Tajiri
born 1965
Invented Pokémon from childhood bug-catching, creating one of the world's largest entertainment franchises
Achievements
- Created Pocket Monsters (1996) — a top-tier global IP
- Revolutionary design centered on “trading”
- The origin of a huge cultural phenomenon across anime, cards and film
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#29 Culture & Arts
Yuji Horii
born 1954
Invented the JRPG itself with Dragon Quest
Achievements
- Dragon Quest (1986) — the origin of Japanese RPGs
- Set the standards of RPG save and progression design
- Former novelist turned game designer
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#30 Culture & Arts
Hayao Miyazaki
born 1941
Raised animation from “children's fare” to art for all humanity
Achievements
- Two Academy Awards for Best Animated Feature
- Spirited Away held Japan's box-office record for years
- Co-founder of Studio Ghibli
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#31 Culture & Arts
Eiichiro Oda
born 1975
Has serialized ONE PIECE for over 25 years — the best-selling manga by a single author in history
Achievements
- ONE PIECE — over 500 million copies, a world record
- Holds the record for the most copies of a manga by a single artist
- Guinness-certified record holder
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#32 Culture & Arts
Hirokazu Kore-eda
born 1962
Keeps asking “what is family?” and carried Japanese cinema to the top at Cannes
Achievements
- Palme d'Or at Cannes (Shoplifters, 2018)
- Multiple international festival awards
- A distinct cinematic language rooted in documentary
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#33 Culture & Arts
Joe Hisaishi
born 1950
Composer of Miyazaki's films and much more — the face of Japanese film music and classical performance
Achievements
- Scores for Studio Ghibli films and many others
- Active conductor and composer in classical music
- Japan's internationally best-known film composer
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#34 Culture & Arts
Tadao Ando
born 1941
Learned architecture without a degree, won the Pritzker Prize, and locked light inside concrete
Achievements
- Pritzker Prize (1995) — architecture's Nobel
- Church of the Light, Row House Sumiyoshi and a new concrete language
- Self-taught master of architecture
Books
- Rensen Renpai (Losing Every Battle)
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#35 Culture & Arts
Kengo Kuma
born 1954
“Erasing architecture” — from concrete to wood and small fragments, a new 21st-century architectural language
Achievements
- Japan National Stadium, SunnyHills and many international works
- International standard-bearer of reinterpreting traditional materials
- A leading voice of architecture's return to nature
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#36 Culture & Arts
Haruki Murakami
born 1949
Turned Japanese literature into a world language; perennial Nobel candidate
Achievements
- Kafka on the Shore, 1Q84 and works translated into 50+ languages
- Franz Kafka Prize, Jerusalem Prize and other honors
- A recurring name in Nobel literature predictions
Books
- Kafka on the Shore
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#37 AI & Computing
Yasunobu Nakamura
Implemented the first superconducting qubits — the first step toward quantum computers
Achievements
- Superconducting-circuit qubits (1999) — the dawn of quantum computing
- Team leader at RIKEN's quantum computer research
- Leads Japan's hub of quantum information physics
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#38 AI & Computing
Daisuke Okanohara
Co-founded Preferred Networks, running at the front of Japan's deep-learning industry
Achievements
- Co-founder of Preferred Networks — Japan's flagship AI company
- Applied deep learning to autonomous driving, drugs and manufacturing
- Continues fundamental machine-learning research
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#39 AI & Computing
Yoichi Ochiai
born 1987
Proposes “digital nature,” rewriting Japan's view of technology from the border of media art and science
Achievements
- Digital Nature — treating technology as an extension of nature
- Levitation and magic-like interaction research
- Professor at University of Tsukuba; media artist
Books
- Tekunorojī no setchi (Grounding Technology)
Links
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#40 AI & Computing
Masahiko Inami
“Superhuman sports” — redefining human ability with body-extending tech (invisibility cloak, shape-changing furniture)
Achievements
- Pioneer of augmented-body engineering and projection mapping
- World-famous for the optical camouflage “invisibility cloak”
- Professor at Tokyo University, advancing cybernics
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#41 AI & Computing
Hiroshi Ishiguro
born 1963
Built his own android twin “Geminoid” and asks what a human is, using robots
Achievements
- World-leading creator of androids: Geminoid, Erica
- Contributed to cognitive science via engineering “humanness”
- Professor at Osaka University; ATR Hiroshi Ishiguro Laboratories
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#42 AI & Computing
Takayuki Furuta
Leads Chiba Institute of Technology's future robotics center, shipping robots that work in disaster zones
Achievements
- Practical rescue robots (deployed at Fukushima Daiichi and elsewhere)
- Research on some of the world's fastest robots
- Built a lab where robots actually get made and deployed
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#43 AI & Computing
Ikuo Takeuchi
born 1946
Inventor of Takeuchi's algorithm and a theorist who built Japan's computer-science foundations
Achievements
- Takeuchi's algorithm — a classic of computer science teaching
- Theoretical foundations of functional languages and graph reduction
- Professor emeritus at Tokyo University, mentor to generations
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#44 AI & Computing
Yutaka Matsuo
For years the longest bridge between Japanese AI research and industry; central to Japan's AI strategy
Achievements
- President of the Japanese Society for Artificial Intelligence
- Deep-learning industrialization and large-model research
- Professor at Tokyo University
Books
- Jinkō chinō to ningen wa kyōshinka suru
Links
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#45 Mathematics
Katsuhiro Nishinari
Created “jamology” — the mathematics of traffic, crowds and ant trails, all with one model
Achievements
- Founder of jamology — the mathematics of flow
- Non-equilibrium statistical mechanics and cellular automata
- Professor at Tokyo University; advised crowd management for the Olympics
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#46 AI & Computing
Nobuo Kawakami
born 1968
Founded Dwango, created Niconico, and has implemented Japanese internet culture from engineering to publishing
Achievements
- Founder of Dwango; creator of Niconico
- Chairman of KADOKAWA, spanning the content industry
- Engaged in education (KADOKAWA DWANGO educational institutions)
Books
- Dejitaru tekunorojī ga rikai dekiru to sekai ga dō mieru no ka
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#47 AI & Computing
Yusuke Narita
born 1986
Brought causal inference and machine learning into Japanese-language discourse, creating a new style of economics
Achievements
- Assistant professor at Yale — causal inference and ML in economics
- Japan's most-watched young economist
- Part of a new generation of academic voices with Yasunori Nomura and others
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#48 Physics & Chemistry
Soichi Noguchi
born 1975
Stayed on the Space Station three times, flying on Shuttle, Soyuz and SpaceX's Crew Dragon
Achievements
- Three vehicles: Discovery (STS-114), Soyuz, Crew Dragon
- The definitive photographer of Earth from orbit
- Now advancing the space industry after JAXA
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#49 Physics & Chemistry
Koichi Wakata
born 1963
First Japanese commander of the Space Station; five spaceflights — the face of Japan in space
Achievements
- First Japanese commander of the ISS
- Five spaceflights across Shuttle, Soyuz and Dragon
- Former JAXA vice president; central to long-term space planning
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#50 Culture & Arts
Yuta Iyama
born 1989
Held every go title simultaneously — the “seven-crowned” master still pushing human records in the AI era
Achievements
- Multiple simultaneous monopolies of all seven major go titles
- Continues to raise Japan's all-time title record
- A representative of Japan's intellectual game culture